Zoster-Associated Pain and Post Herpetic Neuralgia
نویسندگان
چکیده
Herpes zoster (HZ, shingles) is a disease characterized by monolateral vesicular rash and pain, due to reactivation of VZV in the context of a waning specific anti-VZV cell-mediated immunity. Reactivation of VZV produces a new wave of viral replication within the dorsal root ganglia where latency was established after primary infection and its spread downwards to peripheral metameric fibers through the skin, all sensorial manifestations being the expression of VZV-related inflammatory response in sensory ganglia and nerve fibers. Systemic symptoms (fever, headache, malaise) are rare, being observed in some 20% of patients. Other manifestations as facial palsy can be observed in peculiar localizations as zoster oticus, or in particular categories of patients, such as vesicular dissemination in severely immunodepressed patients (Dworkin et al., 2007).
منابع مشابه
Acupuncture in post herpetic neuralgia
Post herpetic neuralgia is a chronic neuropathic pain syndrome that it is characterized by pain in the area of the nerve involved distribution after the disappearance of herpes zoster lesions and it may be persistent, refractory and severe. Various treatments including medication, Botox injections, nerve block and physical modalities have been used in the treatment of this syndrome, each has ...
متن کاملClinical and psychosocial correlates of post-herpetic neuralgia.
Post-herpetic neuralgia is the most challenging and debilitating complication of herpes zoster in the immunocompetent host. Because the effect of treatment is disappointing once the syndrome has developed, it is important to know which factors predict post-herpetic neuralgia occurrence to facilitate selection of herpes zoster patients with a higher risk of developing neuralgia and undertake pre...
متن کاملHerpes zoster and postherpetic neuralgia.
Pain associated with herpes zoster arise from the virul neuritis of the suffered trigeminal or spinal dorsal ganglion. Prolonged neuritis makes an irreversible nerve injury and continuous pain impulse develops a central sensitization. A post-herpetic neuralgia is thought to be a neuropathic pain due to the irreversible nerve injury and sensitization. It is important to treat herpetic pain compl...
متن کاملAssessment of pain in herpes zoster: lessons learned from antiviral trials.
Pain typically accompanies acute herpes zoster and, in a proportion of patients, it persists well beyond rash healing. Pain must therefore be analyzed in trials of antiviral agents in herpes zoster, but different methods have been used to analyze pain in recent published trials. These reports are reviewed and their methodological strengths and weaknesses examined. Based on this review, recommen...
متن کاملA study on efficacy of Pregabalin in acute Herpetic Neuralgia
BACKGROUND Herpes zoster is an intractable painful condition. The pain during first thirty days of onset is known as acute herpetic neuralgia. Multiple treatments using NSAIDS, opioids and tricyclic antidepressants are available but the role of pregabalin in acute Herpetic Neuralgia is not assessed in any of Indian studies. PURPOSE This study was aimed to determine efficacy and safety of Preg...
متن کاملClinical efficacy and tolerability of valacyclovir versus acyclovir in treatment of herpes zoster
Background: Acyclovir, a specific and selective inhibitor of replication of herpesviridae family, has well documented efficacy for speedy rash healing and decreasing pain of herpes zoster. Limited oral bioavailability of acyclovir requires frequent dosing. Valacyclovir is rapidly and almost completely converted to acyclovir in vivo and gives three to fivefold increase in acyclovir bioavailabili...
متن کامل